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Update October 20:

Blanchard McKeithan, 75, and wife Theressa, 74, remain listed in critical condition at the Joseph M. Still Burn Center in Augusta, Georgia after an early morning blaze ripped through their James Island home.

The article provides further detail into the fire, which has been ruled accidental; read it here.

First reporting:

At around 3 a.m. this morning, firefighters responded to a report of a James Island home engulfed in flames and that a woman confined to a wheelchair was still trapped inside.

Two other people living in the house made it out on their own, but the woman, who was trapped inside of her bedroom, has been hospitalized and is reported to be suffering from life-threatening injuries.

The two others who exited the house were also taken to the hospital after the event to be treated for smoke related problems.

The cause of the fire is still under investigation, but, according to the James Island Fire Chief, it doesn't appear suspicious at this time.

The Post and Courier has more on this developing story.